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What is Lyme Testing? ​

Lyme testing is a diagnostic process used to detect infections caused by Borrelia burgdorferi, the bacteria responsible for Lyme disease, and other co-infections transmitted by ticks. By identifying the presence of Lyme-related pathogens or antibodies, this testing helps uncover the root cause of unexplained symptoms.

Conditions a Lyme Disease Test May Address

Bull's-eye
Rash

Neck
Stiffness

Joint Pain
& Swelling

Sensitivity to
Light & Sound

Chronic
Fatigue

Neurological
Symptoms

Sleep
Disturbances

Dizziness&
Lightheadedness

  • Flu-like Symptoms (Fever, Chills, etc.)
  • Muscle Aches & Weakness
  • Bell's Palsy (Facial Paralysis)
  • Severe Headaches
  • Memory Problems & Brain Fog
  • Difficulty Concentrating
  • Mood Changes (depression, Irritability, etc.)
  • Heart Palpitations
  • Numbness & Tingling
  • Anxiety & Panic Attacks
  • Temperature Regulation Issues
  • Recurring Infections
  • many more

Example Lyme Disease Test Panel

Comprehensive Lyme & Co-infection Analysis

Patient ID: LYM-2025-007294 | Collection Date: Aug 8, 2025 | Report Date: Aug 10, 2025

Lyme Disease Testing Complete

Multi-tier analysis including Western Blot confirmation

Complete
22 Total Tests
12 Negative
7 Positive
3 Equivocal

Lyme Disease Screening

Lyme Disease Ab Screen (ELISA) 2.8 Index Reactive < 0.9 Index
Lyme Disease IgM 1.4 Index Positive < 0.9 Index
Lyme Disease IgG 3.2 Index Positive < 1.1 Index

Western Blot IgM Confirmation

23-25 kDa OspC (outer surface protein) Present Positive
39 kDa BmpA (basic membrane protein) Present Positive
41 kDa Flagellin (flagellar protein) Present Positive
IgM Western Blot Interpretation 3/3 bands Positive ≥ 2 bands

Western Blot IgG Confirmation

18 kDa (p18) Absent Negative
23 kDa OspC (outer surface protein) Present Positive
28 kDa (p28) Absent Negative
30 kDa OspA (outer surface protein) Present Positive
39 kDa BmpA Present Positive
41 kDa Flagellin Present Positive
45 kDa (p45) Absent Negative
58 kDa (p58) Present Positive
66 kDa (p66) Present Positive
93 kDa (p93) Equivocal Equivocal
IgG Western Blot Interpretation 6/10 bands Positive ≥ 5 bands

Co-infection Testing

Babesia microti IgG Babesia microti 1:256 Positive < 1:64
Babesia microti IgM 1:32 Negative < 1:64
Ehrlichia chaffeensis IgG Ehrlichia chaffeensis 1:128 Equivocal < 1:64
Anaplasma phagocytophilum IgG Anaplasma phagocytophilum < 1:64 Negative < 1:64
Bartonella henselae IgG Bartonella henselae 1:512 Positive < 1:64
Rocky Mountain Spotted Fever IgG Rickettsia rickettsii < 1:64 Negative < 1:64
Clinical Interpretation: Positive Lyme disease by both ELISA and Western Blot criteria (CDC positive). Co-infections with Babesia microti and Bartonella henselae detected. Results consistent with active or recent Lyme disease with co-infections requiring comprehensive antibiotic therapy.
Lab: IGeneX Laboratory | Method: ELISA & Western Blot | Processed:

Why is Lyme Testing Important?

Lyme disease is often referred to as “the great imitator” because its symptoms mimic those of other conditions, such as chronic fatigue, fibromyalgia, or autoimmune disorders. Early and accurate testing is crucial for confirming a diagnosis, guiding effective treatment, and preventing long-term complications, especially for those with chronic or persistent symptoms.

Key Components of Lyme Testing

Our Lyme testing process includes an in-depth evaluation of key markers to ensure an accurate diagnosis:
Antibody Testing

Identifying the presence of IgM and IgG antibodies specific to Borrelia burgdorferi and other tick-borne infections.

Western Blot

Confirming the presence of Lyme-specific antibodies for enhanced diagnostic accuracy.

Co-Infection Testing

Screening for common co-infections, such as Babesia, Bartonella, and Ehrlichia, which often accompany Lyme disease.

Immune Response Markers

Evaluating cytokines, inflammatory markers, and immune activity to assess how the body is responding to the infection.

PCR Testing

Detecting the DNA of Borrelia or other pathogens to confirm active infections.

CD57 Count

Measuring CD57 natural killer cells, a key marker for assessing chronic Lyme disease and immune health.

Personalized Treatment Plans

After analyzing your Lyme testing results, we’ll create a customized treatment plan tailored to your specific needs. This may include antimicrobial therapies, immune-boosting supplements, dietary changes, detoxification protocols, and strategies to manage inflammation. By addressing both the infection and its underlying effects on the body, our goal is to help you heal, restore energy, and regain optimal health.

The Role of Lyme Testing in Functional Health

Lyme testing is a critical tool in functional health for understanding how tick-borne illnesses impact your overall well-being. By combining Lyme testing with a holistic approach, we look beyond symptoms to identify the root causes of illness. This allows us to craft comprehensive, individualized care plans that support your body’s natural healing processes and promote long-term recovery.

Are You Ready to Start Your Functional Wellness Journey?

Ready to take charge of your health? Begin your journey with a personalized wellness plan focused on addressing root causes, boosting vitality, and empowering you to feel your best every day.

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